1) Availability of proven methods of non-traumatic sampling of HSC and bone marrow (Gratwohl et al., 2013)
2 ) Proven possibility of long-term cryostorage of HSCs without damage and maintaining their functional status (Ragg, 2002)
3) The proven ability of HSC after returning to the bloodstream to independently migrate to the bone marrow and organize hematopoietic niches in it.
4) The presence of direct data on the increase in lifespan and healthspan of old mice when they are transplanted with the bone marrow of young mice (Das et al., 2019; Kovina et al., 2012, 2019; Rozman, 2019)
5) Population-based data on increased life expectancy in people undergoing bone marrow transplantation and HSCs, depending on the youth of the cell donor (a decrease in the age of the donor by 5 years is associated with an increase in the life expectancy of the recipient by 1 year) (Kollman et al., 2016)
Project global tasks