RIF+PSORA+ALLAN and RAP+RIF+ALLAN improve healthspan without tradeoffs. a-c, RIF+PSORA+ALLAN and RAP+RIF+ALLAN shows extension of reproductive span but no effect on total fertility, n=10 worms per condition. d, health span, n>150 worms per condition, P<0.0001, one-way ANOVA. e, resistance to heat stress, n=50 worms per condition. f, resistance to paraquat stress, n=50 worms per condition. g, distance travelled n=50 worms per condition, one-way ANOVA. h, development measured by size of worms n=10 worms per condition. i, basal metabolic rate, n=80 worms per condition, one-way ANOVA. *P<0.01, **P<0.001, ***P<0.0001
Drug synergy slows mortality rate and delays death incidence rate; a, Both the dual and triple synergistic combinations slow the rate of mortality of wild type N2 worms. b, The triple combinations RAP+RIF+ALLAN and RIF+PSORA+ALLAN slows mortality rate in Drosophila Melanogaster. c, RAP+RIF+ALLAN and d, RIF+PSORA+ALLAN delays incidence rate of death of worms.