Mutations in the E(z) и puc genes

The combination in one genome of mutations in several genes, for each of them separately earlier studies have shown an effect on lifespan.

Model organism: Drosophila melanogaster

Number of genes: 2

Type of combination: combination of mutations in selected genes

Difficulty of combination: normal

Gene puc and mutation puc[A251.1F3]

Gene E(z) and mutation E(z)[731]

Gene puc and mutation puc[A251.1F3]

Gene in the FlyBase database
Genomic location of the gene: 3R: coordinates 8,105,332..8,122,294 [+]
Involvement in the signaling pathways/processes: the JNK cascade (c-Jun N-terminal kinase)
Human ortholog: DUSP10
Link to description of DUSP10 in the database of genes associated with aging - Open Genes
Mutation name: A251.1F3
Link to description of the mutation in the FlyBase database
Type of the mutation: P-element
Note: the mutation is lethal in the homozygous state
Detailed description of the mutation: P{lArB} transposon insertion in the second intron of the puc gene
The publication on the mutation
Publication on the impact of gene change on longevity
Mutation effect on longevity: ↑ 38%
Fly line containing this mutation: BDSC (Bloomington Drosophila Stock Center) #11173 P{ry[+t7.2]=lArB}puc[A251.1F3]

Gene in the FlyBase database
Genomic location of the gene: 3L: 10,634,575..10,638,130 [-]
Involvement in the signaling pathways/processes: epigenetics
Human ortholog: EZH2
Link to description of EZH2 in the database of genes associated with aging - Open Genes
Mutation name: 731
Link to description of the mutation in the FlyBase
Type of the mutation: EMS
Detailed description of the mutation: point mutation, substitution of guanine for adenine, which leads to a change in the amino acid sequence: W638term (TGG to TGA)
Publication on the impact of gene change on longevity
Mutation effect on longevity: ↑ 76%
Fly line containing this mutation: BDSC (Bloomington Drosophila Stock Center) #24470 E(z)[731] P{1xFRT.G}2A